1-Bromo-3-chloropropane → HCID 18940712, compound

HRID 355822Notes

Reaction equation

HRID 355822 reaction equation
[CH3:1][N:2]([CH3:26])[S:3]([C:6]1[CH:7]=[C:8]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]1[CH:13]=[N:12][C:11]([C:19]3[O:23][N:22]=[C:21]([CH2:24][CH3:25])[N:20]=3)=[CH:10][C:9]2=1)(=[O:5])=[O:4].[H-].[Na+].Br[CH2:30][CH2:31][CH2:32][Cl:33]>CN(C=O)C>[Cl:33][CH2:32][CH2:31][CH2:30][N:15]1[C:14]2[CH:13]=[N:12][C:11]([C:19]3[O:23][N:22]=[C:21]([CH2:24][CH3:25])[N:20]=3)=[CH:10][C:9]=2[C:8]2[C:16]1=[CH:17][CH:18]=[C:6]([S:3](=[O:5])(=[O:4])[N:2]([CH3:26])[CH3:1])[CH:7]=2

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 24758Sodium hydrideHCID 53671852HCID 53671852, compound

Product 1

HCID 18940712HCID 18940712, compoundYield 7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound was synthesized by mixing (Compound 12) (3.0 g, 8.8 mM), NaH (0.46 g, 11.0 mmol) and 1-bromo-3-chloropropane (1.5 g, 9.7 mmol) in DMF, in the same manner as illustrated in example 3 to give the title compound (0.25 g, 7%). M.p. 223°-224° C.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-44494bba29e84f8782df9b1b1013e6fa
Source dataset
uspto-grants-1998_11
Patent number
US05834482

Reaction notes

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