1-Bromo-3-chloropropane → HCID 54296990, compound

HRID 355825Notes

Reaction equation

HRID 355825 reaction equation
[CH:1]([N:4]([CH:25]=[CH:26][CH3:27])[C:5]1[CH:6]=[C:7]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]1[CH:12]=[N:11][C:10]([C:18]3[O:22][N:21]=[C:20]([CH2:23][CH3:24])[N:19]=3)=[CH:9][C:8]2=1)=[CH:2][CH3:3].[H-].[Na+].Br[CH2:31][CH2:32][CH2:33][Cl:34]>CN(C=O)C>[Cl:34][CH2:33][CH2:32][CH2:31][N:14]1[C:13]2[CH:12]=[N:11][C:10]([C:18]3[O:22][N:21]=[C:20]([CH2:23][CH3:24])[N:19]=3)=[CH:9][C:8]=2[C:7]2[C:15]1=[CH:16][CH:17]=[C:5]([N:4]([CH:1]=[CH:2][CH3:3])[CH:25]=[CH:26][CH3:27])[CH:6]=2

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 24758Sodium hydrideHCID 54192254HCID 54192254, compound

Product 1

HCID 54296990HCID 54296990, compoundYield 28%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound was synthesized by mixing (Compound 18) (1 g, 2.8 mmol), NaH (50% in oil) (0.075 g, 3.1 mmol) and 1-bromo-3-chloropropane (0.44 g, 3.1 mmol) in DMF in the same manner as illustrated in example 3 to give the title compound (0.35 g, 28%).

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-9fdf7782145446e8bea53468c8e25e1b
Source dataset
uspto-grants-1998_11
Patent number
US05834482

Reaction notes

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