反应详情

EDC Hydrochloride (249 mg, 1.3 mmol) was added to a stirred mixture of 2-t-butoxycarbonylaminomethyl-4-chlorophenoxyacetic acid (316 mg, 1.0 mmol), HOBT (176 mg, 1.3 mmol), ethylamine hydrochloride (106 mg, 1.3 mmol) and N-methylmorpholine (0.396 ml, 3.6 mmol) in DMF (4 ml) and the mixture was stirred for 16 h. The reaction was partitioned between ethylacetate and 5% KHSO4 solution and the organic layer was washed with 5% KHSO4 solution, water, NaHCO3 solution and brine, dried (Na2SO4) and evaporated in vacuo to a solid (333 mg) which was used for the next step.

1. customThe reaction was partitioned between ethylacetate and 5% KHSO4 solution
2. washthe organic layer was washed with 5% KHSO4 solution, water, NaHCO3 solution and brine
3. dry with materialdried (Na2SO4)
4. customevaporated in vacuo to a solid (333 mg) which