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温度

0 °C

To a stirred suspension of 3-bromopropylamine hydrobromide (2 g, 9.14 mM) in 40 mL dry THF was added, via hypodermic syringe, benzyl chloroformate (1.64 g, 9.60 mM) at room temperature. After cooling to 0° C., diisopropylethylamine (1.6 mL, 9.20 mM) was added dropwise via syringe and the reaction mixture was allowed to stir at 0° C. for 1 hour. The crude reaction mixture was filtered over a pad of Celite and solvents were evaporated. The residue was flash chromatographed on silica gel, eluting with 10-20-30% EtOAc/hexane to afford 1.56 g desired product as a liquid, homogeneous by TLC in 80:20 hexane-EtOAc;

1. additionwas added, via hypodermic syringe
2. customat room temperature
3. customThe crude reaction mixture
4. filtrationwas filtered over a pad of Celite and solvents
5. customwere evaporated
6. customchromatographed on silica gel
7. washeluting with 10-20-30% EtOAc/hexane