Butyl Chloride → HCID 13689399, compound

HRID 365148Notes

Reaction equation

HRID 365148 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.Cl[CH2:22][CH2:23][CH2:24][CH3:25].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[CH2:22]([N:1]1[CH2:2][CH2:3][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:5][CH2:6]1)[CH2:23][CH2:24][CH3:25]

Participants

5

Reactant 3

HCID 8005Butyl ChlorideHCID 11430Potassium CarbonateHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine

Product 1

HCID 13689399HCID 13689399, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (6.1 g, 0.023 mole), 1-chlorobutane (2.42 g, 0.026 mole), K2CO3 (10 g) and KI (0.1 g) in 100 ml dimethylformamide was heated at 70° C. for a total of 7 hours.

Sources & evidence

ORD record
ord-2b3ee13daf984c449869ae8ff484aa5b
Source dataset
uspto-grants-1986_08
Patent number
US04608374

Reaction notes

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