反应详情

A mixture of 4-chlorobutyronitrile, (0.05 mol) sodium azide (0.20 mol) and anhydrous aluminum chloride (0.05 mol) in 100 ml of dry tetrahydrofuran is refluxed for 24 hours. After cooling to ambient temperature the reaction is acidified with 75 ml of 15% hydrochloric acid while the hydrazoic acid generated is removed by means of an aspirator. The organic and aqueous layers are then separated and the aqueous layer extracted with ethylacetate. The combined organic extracts are dried (magnesium sulfate) and evaporated to give 5-(3-chloropropyl)tetrazole which is used directly in the next step.

1. temperatureis refluxed for 24 hours
2. customgenerated is removed by means of an aspirator
3. customThe organic and aqueous layers are then separated
4. extractionthe aqueous layer extracted with ethylacetate
5. dry with materialThe combined organic extracts are dried (magnesium sulfate)
6. customevaporated