反应详情

4-Methoxybenzyl (2RS)-2-hydroxy-2-[(3R,4R)-3-phenylacetamido-4-[(2RS,3SR)-3-methyltetrahydrofuran-2-ylcarbonylmethylthio]azetidin-2-on-1-yl]acetate (10.406g) was converted to it's chloride with thionyl chloride (3.34g, 2.02ml) and 2,6-lutidine (3.00g, 3.25ml) in tetrahydrofuran (100ml) as described in Example 6(c). The crude chloride in dioxan (80ml) was then converted to the product with tri-n-butylphosphine (6.98ml) also described in 6(c). Flash chromatography on silica gel afforded the title compound as a foam (6.525g, 47%). [Mass spectrum: +ve ion (3-nitrobenzyl alcohol, sodium acetate) MNa+ (763)].