Phenethylamine → HCID 18361059, compound

HRID 383147Notes

Reaction equation

HRID 383147 reaction equation
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(CC)CC)C.[CH2:17]([S:21](Cl)(=[O:23])=[O:22])[CH2:18][CH2:19][CH3:20]>C(Cl)Cl.CCOC(C)=O>[CH2:17]([S:21]([NH:9][CH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)(=[O:23])=[O:22])[CH2:18][CH2:19][CH3:20]

Participants

6

Reactant 3

HCID 1001PhenethylamineHCID 8471TriethylamineHCID 754301-Butanesulfonyl chloride

Product 1

HCID 18361059HCID 18361059, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution at ambient temperature of phenethylamine (200 mg, 1.65 mmol) in CH2Cl2 (2 mL) was added triethylamine (0.35 mL, 2.48 mmol) and butanesulfonyl chloride (0.24 mL, 1.82 mmol). After 4 hours of stirring at ambient temperature, the reaction was diluted with EtOAc and washed with water, 1.0M NaHCO3, and brine. Organic layer dried with Na2SO4, filtered, and concentrated in vacuo.

Workup

  1. washwashed with water, 1.0M NaHCO3, and brine
  2. dry with materialOrganic layer dried with Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-155b5482471144d3bd26dc8be6ea8932
Source dataset
uspto-grants-2001_10
Patent number
US06310095B1

Reaction notes

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