Ethanolamine → HCID 59406686, compound

HRID 383633Notes

Reaction equation

HRID 383633 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:27]=[CH:28][CH:29]=1)[CH2:10][N:11]1[C:16](=[O:17])[CH:15]=[CH:14][C:13]([C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=2)=[N:12]1)=[O:5])[CH3:2].[CH2:30]([CH2:32][NH2:33])[OH:31].CN1CCOCC1.ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:5])[NH:6][C:7]1[CH:29]=[CH:28][CH:27]=[C:9]([CH2:10][N:11]2[C:16](=[O:17])[CH:15]=[CH:14][C:13]([C:18]3[CH:26]=[CH:25][C:21]([C:22](=[O:23])[NH:33][CH2:32][CH2:30][OH:31])=[CH:20][CH:19]=3)=[N:12]2)[CH:8]=1)[CH3:2]

Participants

7

Reactant 5

HCID 700EthanolamineHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 59406714HCID 59406714, compound

Product 1

HCID 59406686HCID 59406686, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

197 mg (0.5 mmol) of 4-[1-(3-ethoxycarbonylaminobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzoic acid are suspended in 2 ml of DMF, and 30 μl (0.5 mmol) of ethanolamine, 112 μl (1 mmol) of 4-methylmorpholine, 70 mg (0.5 mmol) of 1-hydroxybenzotriazole and 194 (1 mmol) of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride are added. The reaction mixture is stirred at room temperature for 24 h and purified by means of prep. HPLC.

Workup

  1. custompurified by means of prep

Sources & evidence

ORD record
ord-50821845032f4ee585d872e62dba7805
Source dataset
uspto-grants-2013_02
Patent number
US08367668B2

Reaction notes

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