反应详情

2-Ethyl-4-methoxy-1H-indole (4.2 g, 24 mmol) is dissolved in 30 mL of DMF and 960 mg (24 mmol) of 60% NaH/mineral oil is added. After 1.5 hours, 2.9 mL (24 mmol) of benzyl bromide is added. After 4 hours, the mixture is diluted with water extracting twice with ethyl acetate. The combined ethyl acetate is washed with brine, dried (MgSO4) and concentrated at reduced pressure. The residue is chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 3.1 g (49% yield) of 2-ethyl-4-methoxy-1-(phenylmethyl)-1H-indole.

1. waitAfter 4 hours
2. washThe combined ethyl acetate is washed with brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated at reduced pressure
5. customThe residue is chromatographed on silica gel
6. washeluted with 20% EtOAc/hexane