Trifluoroacetic acid → HCID 18946135, compound

HRID 399575Notes

Reaction equation

HRID 399575 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH:21]4[CH2:26][CH2:25][N:24]([C:27]([O:29]C(C)(C)C)=O)[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].FC(F)(F)C(O)=O.[CH3:41][N:42](C)[C:43](Cl)=O>C(N(CC)CC)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH:21]4[CH2:26][CH2:25][N:24]([C:27]([N:42]([CH3:43])[CH3:41])=[O:29])[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 6598Dimethylcarbamoyl ChlorideHCID 18967316HCID 18967316, compound

Product 1

HCID 18946135HCID 18946135, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[1-tertbutyloxycarbonyl-4-piperidinylamino]pyrimido[5,4-d]pyrimidine by reaction with trifluoroacetic acid and subsequent reaction with dimethylcarbamoyl chloride and triethylamine. Melting point: 187°-188° C.; Rf : 0.59 (alumina; petroleum ether/ethyl acetate/methanol=10:10:2)

Sources & evidence

ORD record
ord-97fb371be07d48e3875a4c64b09c1647
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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