反应详情

The mixture of 3-(5-amino-4-carboxypyrazol-1-yl)benzoic acid (19.4 g) in diglyme (200 ml) was heated under reflux for 6 hours. To the mixture was added a mixture of ethyl acetate and water, and adjusted to pH 9 with 20% aqueous potassium carbonate solution. The separated aqueous layer was adjusted to pH 3.5 with 6N-hydrochloric acid and the mixture was extracted with a solution of ethyl acetate and tetrahydrofuran. The extract layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo to give 3-(5-aminopyrazol-1-yl)benzoic acid (7.59 g).

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. additionTo the mixture was added
4. extractionthe mixture was extracted with a solution of ethyl acetate and tetrahydrofuran
5. washThe extract layer was washed with brine
6. dry with materialdried over magnesium sulfate
7. customevaporated in vacuo