Diethyl Malonate → HCID 178468432, compound

HRID 400112Notes

Reaction equation

HRID 400112 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][C:12]([CH:15]=[N:16][OH:17])=[C:11](Cl)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](OCC)(=[O:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22].[H-].[Na+]>[Cu]Br>[CH2:24]([O:23][C:21]([C:20]1[C:11]2[CH2:10][CH2:9][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:14][CH2:13][C:12]=2[CH:15]=[N+:16]([O-:17])[C:19]=1[OH:26])=[O:22])[CH3:25]

Participants

5

Reactant 3

HCID 7761Diethyl MalonateHCID 24758Sodium hydrideHCID 866216731-benzyl-4-chloro-5-hydroxyiminomethyl-2,3,6,7-tetrahydro-1H-azepine

Product 1

HCID 178468432HCID 178468432, compound

Reagents, catalysts & solvents 1

HCID 24593copper(I) bromideCatalyst

Procedure

Prepared from 1-benzyl-4-chloro-5-hydroxyiminomethyl-2,3,6,7-tetrahydro-1H-azepine by reaction with diethyl malonate in the presence of sodium hydride and catalytic amounts of copper(I) bromide at 100° C.

Sources & evidence

ORD record
ord-8427a90930f54a9caddc457a71ade9aa
Source dataset
uspto-grants-1998_10
Patent number
US05827849

Reaction notes

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