反应详情

温度

100 °C

A mixture of 6-bromo-2,3-dihydro-1H-isoindol-1-one (150 g, 0.71 mol), Pd(OAc)2 (7.92 g, 0.036 mol), PPh3 (27.9 g, 0.106 mol), Zn(CN)2 (124.6 g, 1.065 mol) and 500 ml of DMF was stirred at 100° C. overnight. Cooled to rt, the solvent was removed and the residue was dissolved in EtOAc. The solid was removed and the filtrate was washed with brine, dried over Na2SO4, evaporated to afford the crude product, which was purified by flash column chromatography on silica gel to afford 3-oxo-2,3-dihydro-1H-isoindole-5-carbonitrile (87.5 g, 78% yield).

1. temperatureCooled to rt
2. customthe solvent was removed
3. dissolutionthe residue was dissolved in EtOAc
4. customThe solid was removed
5. washthe filtrate was washed with brine
6. dry with materialdried over Na2SO4
7. customevaporated
8. customto afford the crude product, which
9. customwas purified by flash column chromatography on silica gel