Hydrochloric Acid → HCID 18536231, compound

HRID 412012Notes

Reaction equation

HRID 412012 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:25]=[CH:24][C:12]([C:13]([NH:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[O:14])=[C:11]([O:26][CH3:27])[CH:10]=1.[Cl:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[Cl:37])[CH2:32]Cl.C(N(CC)CC)C.Cl>CN(C)C=O>[ClH:8].[ClH:28].[Cl:8][C:9]1[CH:25]=[CH:24][C:12]([C:13]([NH:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][N:21]([CH2:32][C:31]3[CH:34]=[CH:35][C:36]([Cl:37])=[C:29]([Cl:28])[CH:30]=3)[CH2:20][CH2:19]2)=[O:14])=[C:11]([O:26][CH3:27])[CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 76093,4-Dichlorobenzyl chlorideHCID 8471TriethylamineHCID 18536253HCID 18536253, compound

Product 1

HCID 18536231HCID 18536231, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of the product of step (a) (4.0 g), 3,4-dichlorobenzylchloride (1.9 ml) and triethylamine (9.0 ml) in N,N-dimethylformamide (20 ml) was stirred at room temperature. The solvent was removed and the residue purified by chromatography (dichloromethane:methanol, 1:0 to 4:1) to give an oil, which was treated with 1.0M ethereal hydrogen chloride to give the product as a solid (3.1 g), m.p. 240-41° C.

Workup

  1. customThe solvent was removed
  2. customthe residue purified by chromatography (dichloromethane:methanol, 1:0 to 4:1)
  3. customto give an oil, which

Sources & evidence

ORD record
ord-4fc7f075034c41b2b4a1f5482de75270
Source dataset
uspto-grants-2003_05
Patent number
US06562825B1

Reaction notes

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