反应详情

3.4 g of methyl chloronicotinate, 5.5 g of potassium carbonate, 3.3 g of 4-pyridylpiperazine and a spatula tipful of 18-crown-6 were heated at 100° C. for 5 h in 75 ml of DMF and then stirred at room temperature for 60 h. The excess potassium carbonate was filtered off, the filtrate was concentrated and the residue was partitioned between water and ethyl acetate. After drying the organic phase over magnesium sulfate and concentrating the solvent, 3.9 g (82%) of the product were obtained.

1. filtrationThe excess potassium carbonate was filtered off
2. concentrationthe filtrate was concentrated
3. customthe residue was partitioned between water and ethyl acetate
4. dry with materialAfter drying the organic phase over magnesium sulfate
5. concentrationconcentrating the solvent