Hydrochloric Acid → HCID 66651457, compound

HRID 418312Notes

Reaction equation

HRID 418312 reaction equation
[CH3:1][N:2]([CH3:30])[C:3]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:8][CH2:7][CH:6]([NH:9][C:10]([C:12]2[C:16]([CH3:17])=[N:15][N:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:13]=2)=[O:11])[CH2:5][CH2:4]1.Cl.[Cl:32][Si](C)(C)C.C(OC(C)C)(C)C>CC(=O)CC.C(OCC)(=O)C.O>[ClH:32].[CH3:30][N:2]([CH3:1])[C:3]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:8][CH2:7][CH:6]([NH:9][C:10]([C:12]2[C:16]([CH3:17])=[N:15][N:14]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:13]=2)=[O:11])[CH2:5][CH2:4]1

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 6397ChlorotrimethylsilaneHCID 7914Diisopropyl EtherHCID 11661359HCID 11661359, compound

Product 1

HCID 66651457HCID 66651457, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6569Methyl Ethyl KetoneSolventHCID 8857Ethyl AcetateSolvent

Procedure

As described for Example 120, 238 mg of the polar diastereoisomer of 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid (4-dimethylamino-4-phenylcyclohexyl)amide were also obtained, which, dissolved in 5 ml 2-butanone and 5 ml ethyl acetate, were converted into the corresponding hydrochloride by adding 10.6 μl water, 75 μl chlorotrimethylsilane and 10 ml diisopropylether (165 mg of white solid).

Workup

  1. customwere also obtained

Sources & evidence

ORD record
ord-a43ab801b3e2476abb33dfd4a17f4a44
Source dataset
uspto-grants-2012_01
Patent number
US08093272B2

Reaction notes

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