Iodoethane → HCID 66703626, compound

HRID 425962Notes

Reaction equation

HRID 425962 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][CH:11]2[CH2:16][C:15]([CH3:18])([CH3:17])[NH:14][C:13]([CH3:20])([CH3:19])[CH2:12]2)[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].I[CH2:28][CH3:29]>CN1CCCC1=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][CH:11]2[CH2:16][C:15]([CH3:18])([CH3:17])[N:14]([CH2:28][CH3:29])[C:13]([CH3:20])([CH3:19])[CH2:12]2)[CH:3]=1

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 66703697HCID 66703697, compound

Product 1

HCID 66703626HCID 66703626, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
90 °C

Procedure

4-Chloro-2-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]benzonitrile was dissolved in N-methyl-2-pyrrolidinone, potassium carbonate and iodoethane were added, followed by stirring at 90° C. By post-treating the reaction liquid, 4-chloro-2-[(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yl)amino]benzonitrile was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-e9783fd8c0ed46cd9c412b4776b86095
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

Loading…