1,2-Dichloroethane → HCID 66703589, compound

HRID 425980Notes

Reaction equation

HRID 425980 reaction equation
ClN1C(=O)CCC1=O.Cl[CH2:10][CH2:11][Cl:12].[CH:13]1([CH2:16][NH:17][C:18]2[N:26]=[CH:25]C=C[C:19]=2[C:20]([OH:22])=[O:21])[CH2:15][CH2:14]1>CN(C=O)C>[Cl:12][C:11]1[CH:25]=[N:26][C:18]([NH:17][CH2:16][CH:13]2[CH2:14][CH2:15]2)=[C:19]([CH:10]=1)[C:20]([OH:22])=[O:21]

Participants

5

Reactant 3

HCID 111,2-DichloroethaneHCID 31398ChlorosuccinimideHCID 28330451HCID 28330451, compound

Product 1

HCID 66703589HCID 66703589, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-Chloro-2,5-pyrrolidinedione was added at room temperature to a 1,2-dichloroethane and DMF solution of 2-[(cyclopropylmethyl)amino]nicotinic acid, followed by stirring for 1 day. By post-treating the reaction liquid, 5-chloro-2-[(cyclopropylmethyl)amino]nicotinic acid was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-0b22ba31ead1410392153aab8721010f
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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