反应详情

The crude 2-(1-propenyloxymethyl)morpholine (32.7 g) was dissolved in an acetone-water (9:1) mixed solvent containing 2.0N hydrochloric acid, followed by heating under reflux for 4 hours. After completion of the reaction, the solvent was evaporated to obtain a crude alcohol compound (41.8 g) as a pale yellow oily substance. Triethylamine (145 ml) was added dropwise to a methylene chloride solution (300 ml) of the crude alcohol compound (41.8 g) under ice-cooling, and triphenylchloromethane (41.5 g, 0.208 mol) was added thereto at the same temperature, followed by stirring for 2 hours. After completion of the reaction, a saturated aqueous solution of sodium hydrogencarbonate (150 ml) was added to the reaction mixture, and the mixture was extracted with chloroform. The extract was dried over magnesium sulfate, the solvent evaporated, and the residue recrystallized from methylene chloride-hexane to give 2-hydroxymethyl-4-tritylmorpholine (48.0 g).

1. additionmixed solvent
2. temperatureby heating
3. temperatureunder reflux for 4 hours
4. customAfter completion of the reaction
5. customthe solvent was evaporated
6. customto obtain a crude alcohol compound (41.8 g) as a pale yellow oily substance
7. temperaturecooling
8. customAfter completion of the reaction
9. extractionthe mixture was extracted with chloroform
10. dry with materialThe extract was dried over magnesium sulfate
11. customthe solvent evaporated
12. customthe residue recrystallized from methylene chloride-hexane