反应详情

To the 4-chloro-2-phenylquinazoline (4.15 mmol) in dry THF (10 ml) was added a solution of 2 M HCl in ether (4 ml). After 5 min the solvents were removed by vacuum. Dry sodium iodide (41.5 mmol) and acetonitrile (30 ml) were added to the hydrochloride salt and refluxed for 4 hrs. The reaction was quenched by the addition of an aqueous solution of 10% K2CO3 and 5% NaHSO3 (15 ml). Extraction with dichloromethane and drying of the combined organic layers was followed by evaporation of solvents under reduced pressure. The resulting crude product was purified by alumina chromatography with (1:10)

1. customAfter 5 min the solvents were removed by vacuum
2. temperaturerefluxed for 4 hrs
3. customThe reaction was quenched by the addition of an aqueous solution of 10% K2CO3 and 5% NaHSO3 (15 ml)
4. extractionExtraction with dichloromethane
5. customdrying of the combined organic layers
6. customwas followed by evaporation of solvents under reduced pressure
7. customThe resulting crude product was purified by alumina chromatography with (1:10)