反应详情

温度

50 °C

To a stirred suspension of Compound 1086 (300 mg, 0.8127 mmol), potassium carbonate (224.6 mg, 1.625 mmol), and 2-bromoethyl methyl ether (169.4 mg, 114.5 μL, 1.219 mmol) was added sodium iodide (182.7 mg, 1.219 mmol). The reaction mixture was heated to 50° C. and allowed to stir overnight. After cooling, the mixture was partioned between EtOAc and water. The organics were with brine, dried over sodium sulfate, and the volatiles removed in vacuo. Purification by silica gel chromatography (0-50% gradient of EtOAc/hexanes) gave 3-(1-(4-(2-methoxyethoxy)-2,3-difluorophenyl)-1H-tetrazol-5-yl)-5-bromopyridin-2-amine (Compound 1089, 120 mg).

1. temperatureAfter cooling
2. dry with materialdried over sodium sulfate
3. customthe volatiles removed in vacuo
4. customPurification by silica gel chromatography (0-50% gradient of EtOAc/hexanes)