反应详情

Oxalyl chloride (8.64 mL, 99.0 mmol) and one drop of DMF were added to a solution of dichloromethane (30 mL) containing 4-(2-cyclopropylethoxy)benzoic acid (9.28 g, 45.0 mmol) prepared in Example 9 (9a) under ice-cooling. The mixture was stirred at room temperature for 1.75 hours, and the solvent was evaporated. Then, the resulting residue was suspended in THF (3 mL). This suspension added dropwise to a 50% THF aqueous solution (120 mL) containing glycine (4.41 g, 58.7 mmol) and triethylamine (15.7 mL, 112 mmol) under ice-cooling. The mixture was stirred at room temperature for 1.5 hours, and then 10% hydrochloric acid (40 mL) was added thereto under ice-cooling. The produced precipitate was collected by filtration, washed with water, and dried by heating under reduced pressure to give 11.4 g of the title compound (powder, yield: 97%).

1. temperaturecooling
2. customthe solvent was evaporated
3. additionThis suspension added dropwise to a 50% THF aqueous solution (120 mL)
4. temperaturecooling
5. stirringThe mixture was stirred at room temperature for 1.5 hours
6. temperatureunder ice-cooling
7. filtrationThe produced precipitate was collected by filtration
8. washwashed with water
9. customdried
10. temperatureby heating under reduced pressure