反应详情

温度

120 °C

K2CO3 (1.07 g, 7.78 mmol) was added to a solution of 2,4-difluoro phenol (0.84 g, 6.48 mmol) in dry DMF (15 ml). 2-Bromoethanol (0.81 g, 6.48 mmol) was added, and the mixture was heated overnight at 120° C. The mixture was cooled, taken up in EtOAc, extracted with water (20 ml), saturated NaCl (4×20 ml), dried over MgSO4, and evaporated under reduced pressure. The product was purified by column chromatography on silica (Hexane:EtOAc 3:1) to give the desired product in 63% yield

1. temperatureThe mixture was cooled
2. extractionextracted with water (20 ml), saturated NaCl (4×20 ml)
3. dry with materialdried over MgSO4
4. customevaporated under reduced pressure
5. customThe product was purified by column chromatography on silica (Hexane:EtOAc 3:1)