反应详情

A solution of 4-hydroxymethyl-5-methyl-furan-2-carboxylic acid methyl ester (16) (1.14 g) in tetrahydrofuran (15 mL) was cooled to 0° C. with stirring and treated with 4-iodophenol (4.6 g), triphenylphosphine (5.5 g) and diisopropylazodicarboxylate (4.2 g). After 10 minutes the cooling bath was removed. After 3 hours the reaction mixture was concentrated in vacuo and taken up in ethyl acetate (100 mL) and washed successively with water (100 mL), 1.0 M aqueous sodium hydroxide solution (100 mL), dried and concentrated in vacuo. The residue was purified by flash chromatography eluting with ethyl acetate/hexane (1:4 by volume) to give compound 20 as a white solid (1.58 g).

1. customAfter 10 minutes the cooling bath was removed
2. concentrationAfter 3 hours the reaction mixture was concentrated in vacuo
3. washwashed successively with water (100 mL), 1.0 M aqueous sodium hydroxide solution (100 mL)
4. customdried
5. concentrationconcentrated in vacuo
6. customThe residue was purified by flash chromatography
7. washeluting with ethyl acetate/hexane (1:4 by volume)