p-Toluenesulfonic acid → HCID 11543601, compound

HRID 462413Notes

Reaction equation

HRID 462413 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH:5]=O.C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.[C-:28]#[N:29].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:28]#[N:29])[CH:7]=[CH:8][C:9]=1[Cl:10]

Participants

6

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 8083MorpholineHCID 8929Sodium CyanideHCID 227103,4-Dichlorobenzaldehyde

Product 1

HCID 11543601HCID 11543601, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 3,4-dichlorobenzaldehyde, p-toluenesulfonic acid, morpholine and sodium cyanide in tetrahydrofuran is reacted to give α-(3,4-dichlorophenyl)-4-morpholineacetonitrile.

Workup

  1. customis reacted

Sources & evidence

ORD record
ord-454a84003c004613ab976c3b985b0f1b
Source dataset
uspto-grants-1985_05
Patent number
US04515791

Reaction notes

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