反应详情

27.2 g of 7β-amino-cephalosporanic acid are added to an aqueous solution of sodium bicarbonate (sodium bicarbonate content: 9.24 g/liter) under stirring, 27.8 g of 1-amino-5-mercapto-1H-tetrazole sodium salt are added thereto. The mixture is stirred at 52°-53° C. in argon gas atmosphere for 3 hours. The mixture is treated with an activated charcoal and adjusted to pH 4.6 with 6 ml of methanesulfonic acid under cooling. The resultant precipitates are collected by filtration, washed with water and then dried. 17.3 g of 7β-amino-3-(1-amino-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid are obtained as ocherous powder.

1. stirringThe mixture is stirred at 52°-53° C. in argon gas atmosphere for 3 hours
2. temperatureunder cooling
3. customThe resultant precipitates
4. filtrationare collected by filtration
5. washwashed with water
6. customdried