Hydrogen Bromide → HCID 131714393, compound

HRID 465042Notes

Reaction equation

HRID 465042 reaction equation
C(O[C:4]([C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([CH2:14][N:15]([CH3:17])[CH3:16])=[N:11][C:10]=2[CH:18]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl.Br>O1CCCC1>[NH2:15][CH2:14][CH2:12][S:13][CH2:4][C:6]1[CH:7]=[CH:8][C:9]2[S:13][C:12]([CH2:14][N:15]([CH3:16])[CH3:17])=[N:11][C:10]=2[CH:18]=1

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 313Hydrochloric AcidHCID 20261662HCID 20261662, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 131714393HCID 131714393, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The benzothiazole derivative (1 g) was subjected to reduction with lithium aluminum hydride (0.6 g) in anhydrous tetrahydrofuran (15 ml). Then, the product was refluxed by heating for 6 hrs in an aqueous solution (7.2 ml) of cystheamine hydrochloride (0.43 g) and 47% hydrobromide to yield 5-[(2-aminoethyl)thiomethyl]-2-dimethylaminomethylbenzothiazole.2hydrobromide (1.52 g).

Workup

  1. temperatureThen, the product was refluxed

Sources & evidence

ORD record
ord-153de6ba13db4a48ad15988ad135835d
Source dataset
uspto-grants-1985_10
Patent number
US04550118

Reaction notes

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