HRID467253

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7397

p-Toluenesulfonyl chloride

C7H7ClO2S

HCID8471

Triethylamine

C6H15N

2 次

结构：CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1

HCID441328

7-Aminocephalosporanic acid

C10H12N2O5S

结构：CON=C(C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1

HCID2724510

(Methoxyimino){2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl}acetic acid

C25H21N3O3S

PRODUCTS

生成物

结构：CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1

HCID131711502

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

Another preferred embodiment of the process of the invention comprises reacting at low temperatures in dimethylacetamide in the presence of triethylamine, tosyl chloride and the syn isomer of 2-(2-tritylamino-4-thiazolyl)-2-methoxyiminoacetic acid and reacting the resulting product with a solution of 7-amino-cephalosporanic acid in methylene chloride in the presence of triethylamine to obtain the syn isomer of 3-acetoxymethyl-7-[2-(2-tritylamino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3f3a1292495f4743810503f73b4d9110
来源数据集: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05159070
来源说明: uspto-grants-1992_10

反应 SMILES

C(N(CC)CC)C.S(Cl)(C1C=CC(C)=CC=1)(=O)=O.[C:19]([NH:38][C:39]1[S:40][CH:41]=[C:42]([C:44](=[N:48][O:49][CH3:50])[C:45]([OH:47])=O)[N:43]=1)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH3:51][C:52]([O:54][CH2:55][C:56]1[CH2:65][S:64][C@@H:59]2[C@H:60]([NH2:63])[C:61](=[O:62])[N:58]2[C:57]=1[C:66]([OH:68])=[O:67])=[O:53]>CC(N(C)C)=O.C(Cl)Cl>[C:52]([O:54][CH2:55][C:56]1[CH2:65][S:64][C@@H:59]2[CH:60]([NH:63][C:45](=[O:47])[C:44]([C:42]3[N:43]=[C:39]([NH:38][C:19]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[S:40][CH:41]=3)=[N:48][O:49][CH3:50])[C:61](=[O:62])[N:58]2[C:57]=1[C:66]([OH:68])=[O:67])(=[O:53])[CH3:51]