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HRID467259

反应详情

EQUATION

反应方程式

HRID 467259 的结构方程式

REACTANTS

反应物

4
结构：Cc1ccc(S(=O)(=O)Cl)cc1
HCID7397

p-Toluenesulfonyl chloride

C7H7ClO2S

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

2 次

结构：CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1
HCID441328

7-Aminocephalosporanic acid

C10H12N2O5S

结构：CON=C(C(=O)O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1
HCID2724510

(Methoxyimino){2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl}acetic acid

C25H21N3O3S

PRODUCTS

生成物

1
结构：O=C(O)C1=CCS[C@@H]2CC(=O)N12
HCID52921562

(6R)-8-Oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C7H7NO3S

AUXILIARIES

试剂、催化剂与溶剂

2
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

结构：CC(=O)N(C)C
溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

The process of claim 1 comprising reacting at low temperature in dimethylacetamide, in the presence of triethylamine, tosyl chloride and the syn isomer of 2-(2-tritylamino-4-thiazolyl)-2-methoxyimino-acetic acid and reacting the resulting product with 7-amino-cephalosporanic acid in methylene chloride in the presence of triethylamine to obtain the syn isomer of 3-acetoxymethyl-7-[2-tritylamino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid.