反应详情

To a solution of 3.6 g of 2-p-chlorophenyl-5-phenylthio-4-oxazoleacetic acid in 10 ml of dimethylformamide were added 4 ml of ethyl bromide and 4 ml of triethylamine. The mixture was stirred at room temperature for 4 hours. To the reaction mixture were added water and ethyl acetate and the resulting mixture was shaken. The organic layer was successively washed with water, diluted hydrochloric acid and water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Recrystallization of the residue from ethanol gave 3.2 g of the title compound, melting at 109°-110° C.

1. stirringthe resulting mixture was shaken
2. washThe organic layer was successively washed with water, diluted hydrochloric acid and water
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customRecrystallization of the residue from ethanol