反应详情

To a reaction flask, equipped with a Dean-Stark trap, is added 3,5-dichloroaniline (16.2 g., 0.10 mole), benzaldehyde (10.6 g., 0.10 mole), p-toluenesulfonic acid monohydrate (0.2 g.), and toluene (100 ml.). The reaction mixture is then warmed to reflux and the water (1.65 ml.) collected by azeotroping. The cooled reaction mixture is treated with charcoal and the filtrate reduced in vacuo to give an amber oil that crystallizes on standing to give N-benzylidene-3,5-dichloroaniline which is recrystallized from pentane. m.p. 52°-53° C.

1. customTo a reaction flask, equipped with a Dean-Stark trap
2. temperatureThe reaction mixture is then warmed
3. temperatureto reflux
4. customthe water (1.65 ml.) collected
5. customby azeotroping
6. customThe cooled reaction mixture
7. customto give an amber oil that
8. customcrystallizes