2-Bromopropane → HCID 19750837, compound

HRID 484101Notes

Reaction equation

HRID 484101 reaction equation
[CH3:1][S:2]([C:5]1[C:6]2[C:7]3[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[C:8]=3[CH:15]=[CH:16][CH:17]=2)(=[O:4])=[O:3].[H-].[Na+].Br[CH:21]([CH3:23])[CH3:22]>CN(C)C=O>[CH3:22][CH:21]([N:10]1[C:11]2[C:7]3[C:6](=[CH:17][CH:16]=[CH:15][C:8]=3[C:9]1=[O:14])[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:13][CH:12]=2)[CH3:23]

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 10131121HCID 10131121, compound

Product 1

HCID 19750837HCID 19750837, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2.5 g of 6-(methylsulfonyl)-benz[cd]indol-2(1H)-one (Example 3), 0.6 g of sodium hydride and 2.7 ml of 2-bromopropane in 100 ml of N,N-dimethylformamide is reacted for 18 hours under argon using the conditions of Example 4 to yield 2.24 g of the desired product as a yellow solid, m.p. 164°-165° C.

Workup

  1. customis reacted for 18 hours under argon using the conditions of Example 4

Sources & evidence

ORD record
ord-6aac75ab899b43d9bbceebc9da54ea2f
Source dataset
uspto-grants-1993_07
Patent number
US05229411

Reaction notes

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