反应详情

Ethyl acetoacetate (2.32 g, 20 mmol) is added to a pre-cold solution of LDA (2.0 M, 20 mL, 40 mmol) in THF (100 mL) at 0° C. After addition, the mixture is stirred for 30 min, then benzyl bromide (3.42 g, 20 mmol) is added dropwise. After stirred at 0° C. for 30 min, the reaction is quenched by 5 N HCl, extracted with ethyl ether. The combined organic layers are washed with water and brine until it is neutral. Concentration and column chromatography yields 1.6 g of the title compounds.

1. additionAfter addition
2. stirringAfter stirred at 0° C. for 30 min
3. customthe reaction is quenched by 5 N HCl
4. extractionextracted with ethyl ether
5. washThe combined organic layers are washed with water and brine until it
6. concentrationConcentration and column chromatography