反应详情

温度

50 °C

Added N-hydroxyphthalimide (1.12 g, 6.87 mmol) and triethylamine (0.96 mL, 6.87 mmol) to a solution of methanesulfonic acid 2-tert-butoxycarbonylaminoethyl ester (1.37 g, 5.73 mmol) in DMF (20 mL). The solution was heated to 50° C. for 16 hours after which time it was cooled to room temperature. The solution was diluted with ethyl acetate, washed with water (2×), saturated K2CO3, dried over Na2SO4 and concentrated to an orange solid (747 mg, 43%) which was taken on without purification.

1. temperaturewas cooled to room temperature
2. washwashed with water (2×), saturated K2CO3
3. dry with materialdried over Na2SO4
4. concentrationconcentrated to an orange solid (747 mg, 43%) which
5. customwas taken on without purification