反应详情

The product of Example 1 step (iv) (0.15 g) was dissolved in DMF (3 ml), N,N-di-isopropylethylamine (0.3 ml) and 3-chlorobenzoyl chloride (0.054 ml) were added. After 2 hours at room temperature, water and ethyl acetate were added, the organic phase separated dried and concentrated. The residue was purified by chromatography (dichloromethane:methanol, 95:5) to give an oil which was dissolved in ether and 1.0M ethereal hydrogen chloride solution added to give the titled product as a solid (0.12 g).

1. customthe organic phase separated
2. customdried
3. concentrationconcentrated
4. customThe residue was purified by chromatography (dichloromethane:methanol, 95:5)
5. customto give an oil which