反应详情

Diol Compound 20 (2.0 g, 5.97 mmol) was added dropwise to a solution of trityl chloride (1.66 g, 6.0 mmol) in anhydrous pyridine (10 mL). The reaction was left to stir for 16 hours after which the solvent was removed by co-evaporation with toluene (2×5 mL). Then, part of the residue (1.0 g, 1.7 mmol) was added dropwise to a suspension of NaH (0.14 g, 3.4 mmol) in THF (50 mL), followed by the addition of MeI (0.22 mL, 3.4 mmol). After 16 hours, TLC analysis showed that the reaction had gone to completion and H2O (5 mL) was added followed by concentration of the reaction mixture. The residue was partitioned between H2O (20 mL) and diethyl ether (100 mL), the organic extract was washed with sat. NaHCO3 (10 mL), dried (MgSO4) and concentrated to give 1-O-oleyl-2-O-methyl-3-O-trityl glycerol (Cornpound 21) as an oil.

1. waitThe reaction was left
2. customwas removed by co-evaporation with toluene (2×5 mL)
3. waitAfter 16 hours
4. additionwas added
5. customThe residue was partitioned between H2O (20 mL) and diethyl ether (100 mL)
6. extractionthe organic extract
7. washwas washed with sat. NaHCO3 (10 mL)
8. dry with materialdried (MgSO4)
9. concentrationconcentrated