反应详情

Potassium carbonate and benzyl bromoacetate were added to DMF solution of ethyl (4-aminophenoxy)acetate and stirred under heating. After adding water and ethyl acetate to the reaction mixture, the organic layer was separated, washed and dried, and then the solvent was evaporated under a reduced pressure. Dichloromethane solution of the thus obtained crude product was mixed with TEA, 4-fluorobenzoyl chloride was added dropwise thereto under ice-cooling and then the reaction solution was stirred. After adding 1 M hydrochloric acid to the reaction solution, the organic layer was separated, washed and dried, and then the solvent was evaporated under a reduced pressure. By purifying the thus obtained crude product by SCG, ethyl {4-[benzyloxycarbonylmethyl-(4-fluorobenzoyl)amino]phenoxy}acetate (colorless oil) was obtained.

1. temperatureunder heating
2. customthe organic layer was separated
3. washwashed
4. customdried
5. customthe solvent was evaporated under a reduced pressure
6. customDichloromethane solution of the thus obtained crude product
7. additionwas added dropwise
8. temperatureunder ice-cooling
9. stirringthe reaction solution was stirred
10. customthe organic layer was separated
11. washwashed
12. customdried
13. customthe solvent was evaporated under a reduced pressure
14. customBy purifying the
15. customthus obtained crude product by SCG