反应详情

To a solution of 4-fluoro-3,3-dimethyl-2-oxobutanoic acid (2.3 g, 15.53 mmol) in DMF (30 mL) was added iodoethane (1.880 mL, 23.29 mmol) and K2CO3 (5.36 g, 38.8 mmol). The reaction mixture was stirred at rt for 18 h. The reaction mixture was diluted with EtOAc and stirred for 10 min. The solid was filtered. The filtration was partitioned between EtOAc and water. The organic phase was washed water, sat. NaCl, and concentrated. The residue was diluted with hexane (˜100 mL) and washed with water (2×30 mL), dried over MgSO4, filtered and concentrated to yield ethyl 4-fluoro-3,3-dimethyl-2-oxobutanoate (2.3 g).

1. stirringstirred for 10 min
2. filtrationThe solid was filtered
3. filtrationThe filtration
4. customwas partitioned between EtOAc and water
5. washThe organic phase was washed water, sat. NaCl
6. concentrationconcentrated
7. additionThe residue was diluted with hexane (˜100 mL)
8. washwashed with water (2×30 mL)
9. dry with materialdried over MgSO4
10. filtrationfiltered
11. concentrationconcentrated