反应详情

温度

0 °C

2-(4-Cyclopropylsulfonylphenyl)-2-tetrahydropyran-4-yloxy-acetic acid (preparation 4) was dissolved in DCM. To this solution was added DMF and cooled to 0° C., followed by the addition of oxalyl chloride under stirring. To this mixture, a solution of 2-aminothiazole and pyridine in DCM was added drop wise at 0° C. and was stirred further for 4 h. at room temperature. The reaction mixture was poured into IN aqueous HCl under stirring, organic layer was again washed with 1N HCl, followed by 5% brine, dried over anhydrous sodium sulfate, solvent was removed under reduced pressure to get the crude compound which was purified by flash chromatography to get the title product.

1. stirringwas stirred further for 4 h. at room temperature
2. stirringunder stirring
3. washorganic layer was again washed with 1N HCl
4. dry with materialdried over anhydrous sodium sulfate, solvent
5. customwas removed under reduced pressure
6. customto get the crude compound which
7. customwas purified by flash chromatography