反应详情

4-bromophenol (10.46 g, 60.5 mmol), 1-bromooctane (15.43 g, 79.9 mmol) and potassiumcarbonate (90 g, 0.65 mol) in N,N-dimethylformamide and was heated to 90° C. for 4 h and then the potassiumcarbonate was filtered off. The reaction mixture was quenched with water and extracted three times with ether. The ether was then washed three times with 1M hydrochloric acid (HCl), one time with water, evaporated, and purified by distillation to obtain 1-bromo-4-(octyloxy)benzene (15.1 g, 52.9 mmol) as a colourless oil.

1. filtrationthe potassiumcarbonate was filtered off
2. customThe reaction mixture was quenched with water
3. extractionextracted three times with ether
4. washThe ether was then washed three times with 1M hydrochloric acid (HCl), one time with water
5. customevaporated
6. distillationpurified by distillation