Hydrochloric Acid → HCID 15076055, compound

HRID 526680Notes

Reaction equation

HRID 526680 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+].[CH2:15]([O:19][C:20](Cl)=[O:21])[CH:16]([CH3:18])[CH3:17].Cl>O>[CH2:15]([O:19][C:20]([NH:1][CH:2]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:10]([OH:12])=[O:11])=[O:21])[CH:16]([CH3:18])[CH3:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6140L-PhenylalanineHCID 14798Sodium HydroxideHCID 62365Isobutyl chloroformate

Product 1

HCID 15076055HCID 15076055, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
12.5 °C

Procedure

L-phenylalanine (50 gm) in water (50 mL) was stirred for about 30 minutes and reaction mass was cooled to 10-15° C. To the resulting solution, aq. NaOH was added followed by addition of isobutylchloroformate (45.5 gm). The reaction mass was stirred at about 25° C. for about 3-4 h and pH was adjusted to 2-3 by addition of conc. HCl at 10-15° C. Reaction mass was stirred at 10-15° C. for 1 h, filtered, washed with water and dried to obtain the title compound.

Workup

  1. customreaction mass
  2. customReaction mass
  3. stirringwas stirred at 10-15° C. for 1 h
  4. filtrationfiltered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-d2b3d2449e24499181d4ddf22104f7d9
Source dataset
uspto-grants-2016_05
Patent number
US09346760B2

Reaction notes

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