反应详情

Methyl 3-tert-butyl-5-hydroxybenzoate (O6.043; 2.18 g) and 1-bromo-2-methoxyethane (1.18 ml) were dissolved in DMF (30 ml) and sodium hydride (301 mg) was added while stirring. After stirring at RT for 2 h, the solvent was drawn off. The residue was taken up in EA, and the mixture was washed with water, dried and concentrated. The residue was purified using silica gel (80 g cartridge, n-heptane/MtB ether gradient of 0-30% in 60 min). 2.0 g of the title compound were obtained.

1. stirringAfter stirring at RT for 2 h
2. washthe mixture was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified
6. customsilica gel (80 g cartridge, n-heptane/MtB ether gradient of 0-30% in 60 min)