Azobisisobutyronitrile → HCID 18442815, compound

HRID 546430Notes

Reaction equation

HRID 546430 reaction equation
[CH3:1][C:2]1[S:6][CH:5]=[N:4][CH:3]=1.[Br:7][N:8]1[C:12](=O)CC[C:9]1=O.N(C(C)(C)C#N)=NC(C)(C)C#N.N1CCOCC1>C(N(CC)CC)C.CN(C)C=O>[Br:7][CH2:1][C:2]1[S:6][CH:5]=[N:4][CH:3]=1.[CH3:9][N:8]([CH2:1][C:2]1[S:6][CH:5]=[N:4][CH:3]=1)[CH3:12]

Participants

8

Reactant 4

HCID 6547AzobisisobutyronitrileHCID 8083MorpholineHCID 67184N-bromobutanimideHCID 1379805-Methylthiazole

Product 2

HCID 18442815HCID 18442815, compoundYield 49.1%HCID 216984015-(Bromomethyl)-1,3-thiazole

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8471TriethylamineSolvent

Procedure

An N,N-dimethylformamide solution of 5-(bromo-methyl)thiazole was prepared by using 5-methylthiazole (5.00 g), N-bromosuccinimide (8.97 g) and α,α′-azobisisobutyronitrile (414 mg) in a similar manner to Referential Example 86, and morpholine (2.20 ml) and triethylamine (7.02 ml) were reacted with this solution to obtain the title compound (1.76 g) as a yellow oil.

Workup

  1. customwere reacted with this solution

Sources & evidence

ORD record
ord-3d307f9cfddc431e96da024d6cf753e3
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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