反应详情

温度

70 °C

A mixture of 1.0 g of 3-(2-pyridyl)-5-bromo-2-methoxypyridine, 0.9 g of phenylboronic acid, 0.3 g of dichlorobistriphenylphosphine palladium and 2 ml of triethylamine was stirred at 120° C. for 1.5 hours in 30 ml of xylene in nitrogen atmosphere. The mixture was returned to room temperature, diluted with ethyl acetate, washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated, and the residue was incorporated with 47% hydrobromic acid and heated at 70° C. for 1 hour. The reaction solution was ice-cooled, diluted with water, and neutralized with potassium carbonate. The resulting precipitates were collected by filtration, washed with water and ether, and then air-dried, to give 0.5 g of the title compound as a pale yellow powder.

1. customwas returned to room temperature
2. washwashed with water and brine
3. dry with materialdried over magnesium sulfate
4. customThe solvent was evaporated
5. temperaturecooled
6. additiondiluted with water
7. customThe resulting precipitates
8. filtrationwere collected by filtration
9. washwashed with water and ether
10. customair-dried