Potassium Carbonate → 4-Methoxy-3-propoxybenzaldehyde

HRID 547924Notes

Reaction equation

HRID 547924 reaction equation
[O:1]=[CH:2][C:3]1[CH:11]=[CH:10][C:7]([O:8][CH3:9])=[C:5]([OH:6])[CH:4]=1.[CH2:12](I)[CH2:13][CH3:14].C([O-])([O-])=O.[K+].[K+].C(OC1C=C(C=CC=1C)C=O)C>CN(C=O)C>[CH3:9][O:8][C:7]1[CH:10]=[CH:11][C:3]([CH:2]=[O:1])=[CH:4][C:5]=1[O:6][CH2:12][CH2:13][CH3:14]

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 12127IsovanillinHCID 336431-IodopropaneHCID 252420583-Ethoxy-4-methylbenzaldehyde

Product 1

HCID 5921094-Methoxy-3-propoxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared by reaction of isovanillin with propyl iodide in DMF using K2CO3 as base in analogy to the preparation of 3-ethoxy-4-methyl-benzaldehyde (intermediate B21, vide infra).

Sources & evidence

ORD record
ord-b7a1077f4664476b9e7e6b449dbd2fb2
Source dataset
uspto-grants-2011_05
Patent number
US07939661B2

Reaction notes

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