Methylamine → 4-Fluoro-2-hydroxy-N-methylbenzamide

DMF (2 drops) was added to a mixture of 4-fluorosalicylic acid (2 g, 12.8 mmol) and oxalyl chloride (2.85 mL, 32.0 mmol) in THF (15 mL). The reaction was stirred for 2 hours then reduced in vacuo. The residue was dissolved in THF (10 mL) and added dropwise to 2M methylamine in THF (32 mL) at 0° C. The reaction was stirred at RT for 72 hours and the THF removed in vacuo. The residue was partitioned between ethyl acetate (80 mL) and water (80 mL). The aqueous layer was further extracted into ethyl acetate (80 mL) and the combined organics washed with brine (50 mL), dried (MgSO4), and reduced in vacuo to give a white solid. The material was chromatographed on silica, eluting with 5-40% ethyl acetate in isohexane, to give the desired compound as a white solid (1.43 g).

1. stirringThe reaction was stirred at RT for 72 hours
2. customthe THF removed in vacuo
3. customThe residue was partitioned between ethyl acetate (80 mL) and water (80 mL)
4. extractionThe aqueous layer was further extracted into ethyl acetate (80 mL)
5. washthe combined organics washed with brine (50 mL)
6. dry with materialdried (MgSO4)
7. customto give a white solid
8. customThe material was chromatographed on silica
9. washeluting with 5-40% ethyl acetate in isohexane

ORD record

ord-8e029baafd9b4297ae5f5f16c4029d5e

Source dataset

uspto-grants-2011_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07943607B2