反应详情

To a solution of 4-[5-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)-imidazo[1,2-a]pyridin-8-ylamino]-benzoic acid (37.0 mg, 0.096 mmol), 4-dimethylaminobenzylamine (15.91 mg, 0.106 mmol) and triethylamine (10.72 mg, 0.047 mL, 0.106 mmol) in dimethylformamide (0.4 mL) under nitrogen is added benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate (55.10 mg, 0.106 mmol). The reaction mixture is then stirred at room temperature for 18 hours. The mixture is then diluted with EtOAc and washed with saturated aqueous NaHCO3. The combined organic layers are dried (MgSO4) and the solvent is removed under reduced. The crude product is purified by reverse phase HPLC to yield the title compound.

1. washwashed with saturated aqueous NaHCO3
2. dry with materialThe combined organic layers are dried (MgSO4)
3. customthe solvent is removed
4. customThe crude product is purified by reverse phase HPLC