Hydrochloric Acid → HCID 67457902, compound

In a nitrogen stream, an n-butyllithium hexane solution (2.44 M, 4.3 mL) was added dropwise to a solution of 1-benzyloxy-2-bromobenzene (2.5 g, 9.5 mmol) in THF (95 mL) at −78° C. and the mixture was stirred at the same temperature for 30 minutes. To this mixture, a solution of 3-trifluoromethoxybenzaldehyde (1.5 g, 7.9 mmol) in THF (32 mL) was added dropwise at −78° C. The reaction mixture was stirred at the same temperature for two hours and furthermore at 0° C. for one hour, and then water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried (anhydrous magnesium sulfate), and then the solvent was distilled under reduced pressure. The obtained residue was treated by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:5)]. The obtained crude product was dissolved in methanol (20 mL) and a 20% palladium hydroxide catalyst (200 mg) was added and furthermore 2N—HCl (0.187 mL) was added thereto. The mixture was stirred under a hydrogen atmosphere for 13 hours. Potassium carbonate (850 mg) was added to the reaction mixture and the mixture was stirred at room temperature for 30 minutes, and then the catalyst was filtered off. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:5)] to obtain the title compound (1.40 g, 99%).

1. stirringThe reaction mixture was stirred at the same temperature for two hours and furthermore at 0° C. for one hour
2. extractionthe mixture was extracted with ethyl acetate
3. washThe organic layer was washed with a saturated sodium chloride aqueous solution
4. dry with materialdried (anhydrous magnesium sulfate)
5. distillationthe solvent was distilled under reduced pressure
6. additionThe obtained residue was treated by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:5)]
7. customThe obtained crude product
8. stirringThe mixture was stirred under a hydrogen atmosphere for 13 hours
9. stirringthe mixture was stirred at room temperature for 30 minutes
10. filtrationthe catalyst was filtered off
11. distillationThe solvent was distilled under reduced pressure
12. customthe obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:5)]

ORD record

ord-4d0da97042fa40439274ceeac9a0483c

Source dataset

uspto-grants-2011_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08048897B2