Sodium hydride → HCID 9930032, compound

HRID 567075Notes

Reaction equation

HRID 567075 reaction equation
[CH3:1][C:2]1([CH3:22])[CH2:11][CH:10]([N:12]([CH2:18][CH2:19][CH3:20])[S:13]([CH2:16][CH3:17])(=[O:15])=[O:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([OH:21])[CH:8]=2)[O:3]1.[H-].[Na+].[CH3:25][O:26][CH2:27][CH2:28]Br>CC(N(C)C)=O>[CH3:25][O:26][CH2:27][CH2:28][O:21][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[O:3][C:2]([CH3:1])([CH3:22])[CH2:11][CH:10]2[N:12]([CH2:18][CH2:19][CH3:20])[S:13]([CH2:16][CH3:17])(=[O:15])=[O:14]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 809722-Bromoethyl methyl etherHCID 17786842HCID 17786842, compound

Product 1

HCID 9930032HCID 9930032, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

0.491 g (1.5 mmol) of N-[2,2-dimethyl-6-hydroxychroman-4-yl]-N-(1-propyl)ethanesulfonamide (Example 22b) was reacted with NaH and 2-methoxyethyl bromide in DMA. 0.27 g of the title compound was obtained from petroleum ether, m.p. 78-80° C.

Sources & evidence

ORD record
ord-64ff4a00b59f490a9b8701d85f7f4346
Source dataset
uspto-grants-2001_01
Patent number
US06177449B1

Reaction notes

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